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Over-expression of CIB1 protein triggers biochemical processes that lead to cardiac hypertrophy: Study

July 14, 2017

Additional analysis of hypertrophied mouse and human heart tissue also detected elevated levels of CIB1 in the sarcolemma, the thin plasma membrane surrounding heart muscle fiber that is important to receiving and serving as a conductor of stimuli.

In experiments designed to monitor the levels, function and molecular interactions of CIB1 during heart injury in living organisms, the scientists conducted hypertension simulation tests on mice. Mice were generated that either lack the CIB1 gene or that over express CIB1 in the heart. Mice with over-expressed cardiac-specific CIB1 exhibited pronounced cardiac hypertrophy and dysfunction with hypertension stimulation, but mice lacking the CIB1 gene showed protection from hypertrophy and dysfunction.

Although the study points to CIB1 and its interaction with calcineurin as possible therapeutic targets, Dr. Molkentin cautioned that extensive additional research is needed before the data becomes clinically applicable to patients.

SOURCE Cincinnati Children's Hospital Medical Center