Geron commences enrollment in imetelstat Phase 2 clinical trial for metastatic breast cancer

July 24, 2017

The research team also studied tiny blood vessels in the brains of mice that had been genetically engineered to lack the eNOS enzyme. Those mice ?? which naturally have higher blood pressure and are prone to insulin resistance compared with normal mice ?? had about a 50 percent reduction in nitrates and nitrites which indirectly reflect nitric oxide production. The eNOS-deficient mice also showed higher levels of amyloid beta peptide in the brain, along with more APP and BACE1.

The study suggests that preserving a healthy blood vessel wall is important in preventing cognitive impairment and ultimately Alzheimer's disease, Katusic said. "On the cardiovascular side we've known for some time that preservation of healthy endothelium is critical to prevent major cardiovascular events. Now it seems this may have important implications for cognitive impairment."

The research could help explain, for instance, how exercise benefits cardiovascular health and the aging brain, Katusic said. Previous research has shown that exercise can delay or prevent cognitive impairment.

"There is a lot of literature showing that every time you exercise, you stimulate the endothelium to produce more nitric oxide," Katusic said. "What we have identified in this paper may help explain the reported (cognitive) benefit of exercise."

SOURCE American Heart Association