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Bardoxolone methyl treatment may reduce stage of CKD, improve eGFR in kidney function

July 18, 2017

The frequency of adverse events was higher in the bardoxolone methyl group compared to the placebo group, with most events mild to moderate in severity. The most frequently reported adverse event in the bardoxolone methyl group was muscle spasm.

"We are very pleased to see that bardoxolone methyl reduced the stage of disease and improved measures of kidney function in the majority of patients receiving the drug," said Warren Huff, CEO of Reata. "We are hopeful that these results will be further validated at the end of the study, and we look forward to initiating a Phase 3 study in the first half of 2011."

"Extensive preclinical and clinical experience with bardoxolone methyl have suggested this drug holds promise as a new approach for the treatment for CKD ?? one that has the potential to help prevent patients from progressing to the later stages of the disease and dialysis," said Eugene Sun, M.D., vice president, Global Pharmaceutical Development, Abbott.  "We look forward to expanding our knowledge further in future studies."

SOURCE Abbott