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Avaxia receives BARDA contract to develop new radiation mitigation drug

November 07, 2017

In 56 per cent of cases the cause of the acute pancreatitis was alcohol-related or of uncertain or unknown origin (66 per cent were men) and in 44 per cent of cases it was gallstone related (48 per cent were men). The average age of the patients with pancreatitis was 64 years.Single occasion alcohol consumption, including wine, beer and spirits, was highest in males and younger patients.High single occasion spirits consumption was associated with higher levels of diabetes (nine per cent) than low alcohol consumption (six per cent)People who had never smoked, were more highly educated and regularly ate fruit and vegetables were less likely to drink large quantities of beer and spirits.Eliminating patients with gallstone-related disease did not affect the overall results and only reduced the overall risk of an acute attack after consuming five measures of spirits from 52 per cent to 39 per cent.       

"When alcohol metabolises it induces oxidative stress and this in turn can lead to damaged pancreatic tissue" says Dr Sadr-Azodi.

"However research has shown that alcohol on its own is not sufficient to cause acute pancreatitis. Our study suggests that there are constituents in spirits that are not present in wine and beer and that they can cause acute pancreatitis, either on their own or in combination with alcohol."

The authors are calling for more research into the association between increased spirit consumption and acute pancreatitis, with a greater focus on constituents other than the alcohol.

Source: onlinelibrary.wiley/doi/10.1002/bjs.7632/pdf